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Search Results for " oncogene met "

Targets Recommended: c-Met/HGFR

5

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8825	Capmatinib 2HCl.H2O INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) 是一种具有潜在抗肿瘤活性的原癌基因 c-Met (HGFR) 的口服生物可利用抑制剂。
T1963	Capmatinib NVP-INC280,INC-280,卡马替尼,INCB28060	Apoptosis; c-Met/HGFR	Apoptosis; Tyrosine Kinase/Adaptors
	Capmatinib (INCB28060) 是一种具有口服活性的，选择性的，ATP 竞争性的c-Met 激酶抑制剂，IC50值为0.13 nM。它有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移，可诱导细胞凋亡，有抗肿瘤活性。
T3455	Merestinib LY2801653	Discoidin Domain Receptor (DDR); FLT; c-Met/HGFR; ROS; ROS Kinase	Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Merestinib (LY2801653) 是一种有效的口服生物可利用的具有抗肿瘤活性的c-Met 抑制剂。
T71187	Foretinib phosphate
	Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
T62911	Dalmelitinib
	Dalmelitinib 是一种选择性的、口服具有活力的 c-Met 激酶抑制剂 (IC50: 2.9 nM)，能够结合 c-Met 的 ATP-binding 区域。 Dalmelitinib 能够诱导 MET 的磷酸化，部分或完全抑制 AKT 和 ERK 的磷酸化。Dalmelitinib 对癌细胞 (c-Met 癌基因扩增) 的增殖表现出有效的抑制作用，可以用于研究癌症（如非小细胞肺癌）。

化合物

Capmatinib 2HCl.H2O

Cat.No: T8825

Synonym: INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O

Target: c-Met/HGFR

Cat.No: T1963

Synonym: NVP-INC280,INC-280,卡马替尼,INCB28060

Target: Apoptosis, c-Met/HGFR

Cat.No: T3455

Synonym: LY2801653

Target: Discoidin Domain Receptor (DDR), FLT, c-Met/HGFR, ROS, ROS Kinase

Foretinib phosphate

Cat.No: T71187

Cat.No: T62911

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) MET proto-oncogene, receptor tyrosine kina...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His) MET proto-oncogene, receptor tyrosine kina...	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.
TMPY-01296	HGFR/c-Met Protein, Human, Recombinant (His) AUTS9,MET proto-oncogene, receptor tyrosin...	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759.
TMPY-00546	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc) MET proto-oncogene, receptor tyrosine kina...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.3 kDa and the accession number is G7MM61.
TMPY-02068	HGFR/c-Met Protein, Canine, Recombinant (His) MET proto-oncogene, receptor tyrosine kina...	Canine	HEK293 Cells
	HGFR/c-Met Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is Q75ZY9.
TMPY-03581	HGFR/c-Met Protein, Rat, Recombinant (hFc) MET proto-oncogene, receptor tyrosine kina...	Rat	HEK293 Cells
	HGFR/c-Met Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.1 kDa and the accession number is Q2IBC7.
TMPY-06278	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated MET proto-oncogene, receptor tyrosine kina...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is NP_001162100.2.
TMPY-00634	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant MET proto-oncogene, receptor tyrosine kina...	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 102.3 kDa and the accession number is G7MM61.
TMPY-06657	HGFR/c-Met Protein, Rat, Recombinant (His) MET proto-oncogene, receptor tyrosine kina...	Rat	HEK293 Cells
	HGFR/c-Met Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102.53 kDa and the accession number is XP_006236191.1.
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi) cMET,Met (c-Met),MET,HGF...	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPK-00499	HGFR/c-Met Protein, Cynomolgus, Recombinant (His) MET,oncogene MET,cMET,SF...	Cynomolgus	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPY-01895	HGFR/c-Met Protein, Mouse, Recombinant (hFc) c-Met,AI838057,MET proto-oncogene...	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.
TMPY-04379	HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) MET proto-oncogene, receptor tyrosine kina...	Human	Baculovirus Insect Cells
	HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.
TMPJ-00415	HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated SF receptor,HGF receptor,Scatter factor receptor,Tyrosine-pr...	Human	HEK293 Cells
	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domai...
TMPY-05607	HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated MET proto-oncogene, receptor tyrosine kina...	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 104.9 kDa and the accession number is A0A024R759.
TMPY-00718	HGFR/c-Met Protein, Human, Recombinant (His & hFc) DFNB97,RCCP2,AUTS9,MET proto-oncogene, rec...	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 129.5 kDa and the accession number is A0A024R759.
TMPY-05441	HGFR/c-Met Protein, Human, Recombinant (hFc) HGFR,DFNB97,RCCP2,AUTS9,c-Met,MET proto-	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.4 kDa and the accession number is A0A024R759.
TMPK-00634	MSPR/Ron Protein, Human, Recombinant (His) MST1R,RON,MSP R,CD136,PTK8,p185-Ron,MSPR,CDw136,MSP receptor	Human	HEK293 Cells
	Macrophage-stimulating protein (MSP) is a serum protein belonging to the plasminogen-related growth factor family. The specific receptor for MSP is the RON (recepteur d'origine nantais) receptor tyrosine kinase - a member of the MET proto-oncogene family. Activation of RON by MSP exerts dual functions on macrophages.

重组蛋白

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-00548

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01896

Species: Mouse

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His)

Cat.No: TMPY-01296

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc)

Cat.No: TMPY-00546

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Canine, Recombinant (His)

Cat.No: TMPY-02068

Species: Canine

Expression System: HEK293 Cells

HGFR/c-Met Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03581

Species: Rat

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated

Cat.No: TMPY-06278

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant

Cat.No: TMPY-00634

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Rat, Recombinant (His)

Cat.No: TMPY-06657

Species: Rat

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00457

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00499

Species: Cynomolgus

Expression System: HEK293 Cells

HGFR/c-Met Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01895

Species: Mouse

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST)

Cat.No: TMPY-04379

Species: Human

Expression System: Baculovirus Insect Cells

HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated

Cat.No: TMPJ-00415

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05607

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00718

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05441

Species: Human

Expression System: HEK293 Cells

MSPR/Ron Protein, Human, Recombinant (His)

Cat.No: TMPK-00634

Species: Human

Expression System: HEK293 Cells

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